闭环深部脑刺激在改善帕金森氏症方面具有优势

Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism

Boris Rosin,^1,* Maya Slovik,¹ Rea Mitelman,^1,2 Michal Rivlin-Etzion,^1,2 Suzanne N. Haber,³ Zvi Israel,⁴ Eilon Vaadia,^1,2,5 and Hagai Bergman^1,2,5

¹Department of Medical Neurobiology (Physiology), The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical Association School of Medicine and Hadassah University Hospital, Jerusalem 91120, Israel

²The Interdisciplinary Center for Neural Computation, Givat Ram Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

³Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA

⁴Center for Functional & Restorative Neurosurgery, The Hebrew University-Hadassah Medical Association School of Medicine and Hadassah University Hospital, Jerusalem 91120, Israel

⁵The Edmond & Lily Safra Center for Brain Sciences, Givat Ram Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

*Correspondence: boris.rosin@mail.huji.ac.il

Accepted: 2011 by Neuron

摘要：连续高频深部脑刺激（DBS）是用于晚期帕金森氏病（PD）管理的广泛使用的疗法。但是，DBS效应的潜在机制仍然是神秘的，并且是正在进行辩论的主题。在这里，我们提出并测试PD的1-甲基-4-苯基-1,2,3,6-tet-rahydropyridine（MPTP）灵长类动物模型的PD的闭环刺激策略。应用苍白质闭环刺激可导致基底神经节（BG）放电速率和模式改变之间的分离，从而提供对PD病理生理学的见识。此外，与标准开环DBS和匹配的控制刺激范例相比，皮质-苍白球闭环刺激对运动障碍以及皮质和苍白球放电模式的影响显着更大。因此，通过调节病理振荡活动而不是BG皮质网络的放电速率，闭环DBS范式可以提供对晚期PD的更有效管理。这样的策略有可能在另外的脑部疾病中有效，其中可以识别病理性神经元放电模式。

翻译原文：Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism

翻译稿件：闭环深部脑刺激在改善帕金森氏症方面具有优势