对丘脑底核的刺激逆转中额叶对决策阈值的影响

Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold

 James F Cavanagh¹, Thomas V Wiecki¹, Michael X Cohen^2,3, Christina M Figueroa1, Johan Samanta^4,5, Scott J Sherman⁴ & Michael J Frank^1,6,7

¹Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, Rhode Island, USA.

²Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.

³Department of Physiology, University of Arizona, Tucson, Arizona, USA.

⁴Department of Neurology, University of Arizona, Tucson, Arizona, USA.

⁵Banner Good Samaritan Medical Center, Phoenix, Arizona, USA.

 ⁶Department of Psychiatry, Brown University, Providence, Rhode Island, USA.

 ⁷Brown Institute for Brain Science, Providence, Rhode Island, USA.

Correspondence should be addressed to J.F.C. (jim.f.cav@gmail.com) or M.J.F. (michael_frank@brown.edu).

Accepted: 15 June 2020 by Neuroscience

(translated by zang jie)

摘要：驯服自己的冲动需要花费时间和精力。尽管内侧前额叶皮层（mPFC）广泛地牵涉到对行为的努力控制中，但据认为丘脑下核（STN）可以通过在决策冲突期间阻止皮质-纹状体功能发挥作用，从而为正确的决策做出准备。使用决策的漂移扩散模型，我们发现mPFC活性的试验间增加（EEG theta功率，4–8Hz）与证据积累的阈值（决策阈值）随冲突的增加而相关。帕金森氏病患者对STN的深层大脑刺激逆转了这种关系，从而导致了冲动的选择。此外，在这些相同的高冲突决策中，STN区域的颅内记录显示活动增加（2.5-5Hz）。在这些慢频带中的活动可能反映了皮质-基底神经节沟通调节决策过程的神经基础。

翻译原文：Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold

翻译稿件：对丘脑底核的刺激逆转中额叶对决策阈值的影响