深层脑刺激的机制：抑制，激发或破坏？

Mechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption?

Satomi Chiken¹ and Atsushi Nambu¹

¹Division of System Neurophysiology, National Institute for Physiological Sciences and Department of Physiological Sciences, SOKENDAI (The Graduate University for Advanced Studies), Myodaiji, Okazaki, Japan

Accepted: 15 June 2020 by Neuroscientist

(translated by zang jie)

摘要：将高频电刺激应用于脑深部结构的深部脑刺激（DBS）现在已为各种神经和精神疾病提供了有效的治疗选择。针对苍白球，丘脑下核和丘脑内部区域的DBS用于治疗运动障碍的症状，例如帕金森氏病，肌张力障碍和震颤。但是，DBS有益作用的潜在机制仍然知之甚少，并且仍在争论中：DBS是否抑制或激发局部神经元？在这篇简短的评论中，我们想介绍我们最近关于DBS生理机制的工作，并提出另一种解释：DBS分离输入和输出信号，从而导致异常信息流通过刺激部位而受到干扰。

翻译原文：Mechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption?

翻译稿件：深层脑刺激的机制：抑制，激发或破坏？