THE DUAL EFFECT OF MEMBRANE POTENTIAL ON SODIUM CONDUCTANCE IN THE GIANT AXON OF LOLIGO
BY A. L. HODGKIN AND A. F. HUXLEY
From the Laboratory of the Marine Biological Association, Plymouth,and the Physiological Laboratory, University of Cambridge
(Received 24 October 1951)
This paper contains a further account of the electrical properties of the giant axon of Loligo. It deals with the inactivation process which gradually reduces sodium permeability after it has undergone the initial rise associated with depolarization. Experiments described previously (Hodgkin & Huxley,1952a, b) show that the sodium conductance always declines from its initial maximum, but they leave a number of important points unresolved. Thus they give no information about the rate at which repolarization restores the ability of the membrane to respond with its characteristic increase of sodium conductance. Nor do they provide much quantitative evidence about the influence of membrane potential on the process responsible for inactivation.These are the main problems with which this paper is concerned. The experimental method needs no special description, since it was essentially the same as that used previously (Hodgkin, Huiley & Katz, 1952; Hodgkin & Huxley,1952b).
H-H模型(d)原文
膜电位对枪乌贼巨轴中钠电导率的双重影响
A. L. HODGKIN 和A. F. HUXLEY
来自海洋生物学会实验室,普利茅斯和剑桥大学生理学实验室
本文进一步介绍了枪乌贼巨轴突的电学特性。它涉及“失活”过程,该过程在经历与去极化相关的初始升高后逐渐降低钠渗透性。之前描述的实验(Hodgkin&Huxley,1952a,b)表明钠电导总是从其初始最大值下降,但是它们留下了许多未解决的重要点。因此,它们没有给出关于复极化恢复膜响应其特征性钠电导增加的能力的速率的信息。它们也没有提供关于膜电位对失活过程的影响的定量证据。这些是本文所涉及的主要问题。实验方法不需要特别描述,因为它基本上与先前使用的相同。(Hodgkin,Huiley&Katz,1952; Hodgkin&Huxley,1952b)
H-H模型(d)翻译稿