Somato-dendritic mechanisms underlying the electrophysiological properties of hypothalamic magnocellular neuroendocrine cells:A multicompartmental model study

Abstract Magnocellular neuroendocrine cells (MNCs) of the hypothalamus synthesize the neurohormones vasopressin and oxytocin, which are released into the blood and exert a wide spectrum of actions, including the regulation of cardiovascular and reproductive functions. Vasopressin- and oxytocin-secreting neurons have similar morphological structure and electrophysiological characteristics. A realistic multicompartmental model of a MNC with a bipolar branching structure was developed and calibrated based on morphological and in vitro electrophysiological data in order to explore the roles of ion currents and intracellular calcium dynamics in the intrinsic electrical MNC properties.

房室模型之翻译原件

下丘脑的大细胞神经内分泌细胞（MNCs）合成神经激素血管加压素和催产素，释放到血液中并发挥广泛的作用，包括调节心血管和生殖功能。血管加压素和催产素分泌神经元具有相似的形态结构和电生理特征。基于形态学和体外电生理学数据开发并校准了具有双极分支结构的 MNC 的现实多室模型，以探索离子电流和细胞内钙动力学在内在电 MNC 特性中的作用。

房室模型之翻译稿