Influence of dendritic structure on firing pattern in model neocortical neurons

Neurons display a wide range of dendritic morphologies, ranging from compact arhorizations to highly elaborate branching patterns.  In  vitro  electrical recordings from these neurons have revealed a correspondingly diverse range of intrinsic firing patterns, including non-adapting, adapting and bursting typeszy3. This heterogeneity of electrical responsivity has generally been attributed to variability in the types and densities of ionic channels. We show here, using compartmental models of reconstructed cortical neurons, that an entire spectrum of firing patterns can be reproduced in a set of neurons that share a common distribution of ion channels and differ only in their dendritic geometry. The essential behaviour of the model depends on partial electrical coupling of fast active conductances localized to the soma and axon and slow active currents located throughout the dendrites, and can be reproduced in a two-compartmentmodel.

房室模型之翻译原文 

新皮层神经元展示了广泛的树枝状形态，从紧凑的分支到高度精细的分支模式。来自这些神经元的体外电记录揭示了相应多种范围的内在发射模式，包括非适应性，适应性和破裂型（2,3）。电响应性的这种异质性通常归因于离子通道的类型和密度的可变性。我们在这里展示，使用重建的皮质神经元的区室模型，可以在一组共享离子通道的共同分布并且仅在它们的树突几何形状上不同的神经元中再现整个激发模式。
房室模型之翻译稿