四种皮质间神经元亚型树突状树的守恒特性
Conserved properties of dendritic trees in four cortical interneuron subtypes
Yoshiyuki Kubota1,2,3, Fuyuki Karube1,3, Masaki Nomura3,4, Allan T. Gulledge5, Atsushi Mochizuki6, Andreas Schertel7 & Yasuo Kawaguchi1,2,3
1Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, 444-8787, Japan,
2Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, 444-8585, Japan,
3Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Tokyo, 102-0075, Japan,
4Laboratory for Cellular Systems Modeling, RIKEN Research Center for Allergy and Iμmunology (RCAI), Yokohama, 230-0045, Japan, 5Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, NH 03756, U.S.A,
6Theoretical Biology Laboratory, RIKEN Advanced Science Institute, Wako, 351-0198, Japan,
7Carl Zeiss NTS GmbH, Carl-Zeiss-Str. 56, D-73447 Oberkochen,Germany.
树突树影响突触整合和神经元的兴奋性,但似乎以相当任意的模式发展。利用电子显微镜和序列重建技术,我们分析了四种形态不同的新皮质中间神经元亚型的树突树,揭示了两种共同的基本组织原理。首先,树突内任何给定点的横截面积与该点远端所有树枝段的总长度成正比。与这一观察结果一致,总横截面积在分叉点几乎完全守恒。第二,在更近、直径更大的树突位置,树突横截面逐渐变得更椭圆。最后,计算机模拟显示这些守恒的形态学特征限制了细胞体EPSPs的距离依赖性滤波,并促进了细胞体去极化分布到所有的树突房室。因为所有研究的中间神经元都具有这些特征,所以它们可能代表了树突树不同形态的共同组织原理。
翻译稿件:四种皮质间神经元亚型树突状树的守恒特性
翻译原件:Conserved properties of dendritic trees in four cortical interneuron subtypes