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A Computational Model of Inhibitory Control
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关键词:-response inhibition, neural network model, cognitive control, prefrontal cortex, basal ganglia |
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Planning and executing volitional actions in the face of conflicting habitual responses is a critical aspect of human behavior. At the core of the interplay between these 2 control systems lies an override mechanism that can suppress the habitual action selection process and allow executive control to take over. Here, we construct a neural circuit model informed by behavioral and electrophysiological data collected on various response inhibition paradigms. This model extends a well-established model of action selection in the basal ganglia by including a frontal executive control network that integrates information about sensory input and task rules to facilitate well-informed decision making via the oculomotor system. Our simulations of the anti-saccade, Simon, and saccade-override tasks ensue in conflict between a prepotent and controlled response that causes the network to pause action selection via projections to the subthalamic nucleus. Our model reproduces key behavioral and electrophysiological patterns and their sensitivity to lesions and pharmacological manipulations. Finally, we show how this network can be extended to include the inferior frontal cortex to simulate key qualitative patterns of global response inhibition demands as required in the stop-signal task.
Frank模型参考原文1
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